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Effect of eradication of Helicobacter pylori on genetic instabilities in gastric intestinal metaplasia
Author(s) -
TANAKA A.,
WATARI J.,
TANABE H.,
MAEMOTO A.,
FUJIYA M.,
ASHIDA T.,
DAS K. M.,
KOHGO Y.
Publication year - 2006
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2006.00045.x
Subject(s) - helicobacter pylori , gastroenterology , medicine , intestinal metaplasia , loss of heterozygosity , microsatellite instability , incidence (geometry) , cancer , prospective cohort study , atrophic gastritis , gastritis , allele , biology , microsatellite , gene , genetics , physics , optics
Summary Background There is little evidence of changes in genetic variations in gastric intestinal metaplasia (GIM) after the eradication of Helicobacter pylori ( H. pylori ). Aim To investigate the effects of H. pylori eradication on genetic GIM variability in patients with and without gastric cancer in a one‐year prospective study. Methods We analysed microsatellite instability (MSI) and loss of heterozygosity (LOH) in GIM. Subjects included Gr. A ( n = 39): chronic gastritis, and Gr. B ( n = 53): intestinal‐type early gastric cancer patients who underwent endoscopic mucosal resection ( n = 25) and surgical resection ( n = 28). Results The frequency of incidence of MSI in GIM was 10.3% and 28.3% for Gr. A and Gr. B, respectively. Gr. B showed a significantly (p = 0.03) higher incidence rate than Gr. A for MSI, but not for LOH. The frequency of MSI declined in both groups post‐eradication, and patients that were positive for MSI before treatment were negative after H. pylori eradication. Unfortunately, however, GIM scores did not decline significantly post‐treatment for either group. Conclusions MSI in GIM may be associated with gastric carcinogenesis. H. pylori eradication reduced MSI during the one‐year post‐treatment period, although no histological improvement in GIM was observed. These changes in MSI may explain the decrease in gastric cancer incidence after the eradication of H. pylori .