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Esomeprazole 20 mg vs. pantoprazole 20 mg for maintenance therapy of healed erosive oesophagitis: results from the EXPO study 1
Author(s) -
LABENZ J.,
ARMSTRONG D.,
LAURITSEN K.,
KATELARIS P.,
SCHMIDT S.,
SCHÜTZE K.,
WALLNER G.,
JUERGENS H.,
PREIKSAITIS H.,
KEELING N.,
NAUCLÉR E.,
ADLER J.,
EKLUND S.
Publication year - 2005
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2005.02643.x
Subject(s) - esomeprazole , pantoprazole , medicine , gastroenterology , heartburn , reflux , esophagitis , omeprazole , disease
Summary Background : Following initial healing of erosive oesophagitis, most patients require maintenance therapy to prevent relapse. Aim : To compare endoscopic and symptomatic remission rates over 6 months’ maintenance therapy with esomeprazole or pantoprazole (both 20 mg once daily) in patients with healed erosive oesophagitis. Methods : Patients with symptoms of gastro‐oesophageal reflux disease and endoscopically confirmed erosive oesophagitis at baseline were randomized to receive esomeprazole 40 mg or pantoprazole 40 mg for up to 8 weeks. Patients with healed erosive oesophagitis and free of moderate/severe heartburn and acid regurgitation at 4 weeks or, if necessary, 8 weeks entered the 6‐month maintenance therapy phase of the study. Results : A total of 2766 patients (63% men; mean age 50 years) received esomeprazole 20 mg ( n = 1377) or pantoprazole 20 mg ( n = 1389) and comprised the intention‐to‐treat population. Following 6 months of treatment, the proportion of patients in endoscopic and symptomatic remission was significantly greater for those receiving esomeprazole 20 mg (87.0%) than pantoprazole 20 mg (74.9%, log‐rank test P < 0.0001). Esomeprazole 20 mg produced a higher proportion of patients free of moderate to severe gastro‐oesophageal reflux disease symptoms and fewer discontinuations because of symptoms than pantoprazole 20 mg (92.2% vs. 88.5%, P < 0.001). Conclusions : Esomeprazole 20 mg is more effective than pantoprazole 20 mg for maintenance therapy following initial healing of erosive oesophagitis and relief of gastro‐oesophageal reflux disease symptoms.