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Omeprazole delays gastric emptying in healthy volunteers: an effect prevented by tegaserod
Author(s) -
TOUGAS G.,
EARNEST D. L.,
CHEN Y.,
VANDERKOY C.,
ROJAVIN M.
Publication year - 2005
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2005.02528.x
Subject(s) - omeprazole , gastric emptying , medicine , tegaserod , gastroenterology , proton pump inhibitor , placebo , stomach , crossover study , constipation , alternative medicine , pathology
Summary Background : Proton‐pump inhibitors effectively suppress stomach acidity. They are widely used for treating gastro‐oesophageal reflux disease and related conditions. While generally safe, omeprazole and other proton‐pump inhibitors can delay gastric emptying. Aim : To test the hypothesis that tegaserod can normalize or prevent omeprazole‐induced delay in gastric emptying. Methods : This was a randomized, double‐blind, placebo‐controlled, parallel group study in 40 healthy male volunteers. After informed consent and screening, qualified volunteers were treated with unblinded omeprazole 20 mg b.d. and either blinded tegaserod 6 mg t.d.s. (active treatment group) or placebo‐matching tegaserod t.d.s. (control group) for 14 days. Gastric emptying was assessed before and after treatment, using a scintigraphy method. Results : Omeprazole monotherapy significantly delayed gastric emptying expressed by duration of lag‐phase ( P < 0.007), time to gastric half‐emptying ( P < 0.003), and gastric retention of the meal at 60 ( P < 0.002) and 120 min ( P < 0.04) after its ingestion. Tegaserod taken together with omeprazole effectively prevented development of the above effects. Combined treatment was safe and well tolerated. Conclusion : Concomitant administration of tegaserod 6 mg t.d.s. prevented development of the delayed gastric emptying induced by omeprazole monotherapy.