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Clinical features of gastric cancer discovered after successful eradication of Helicobacter pylori : results from a 9‐year prospective follow‐up study in Japan
Author(s) -
Kamada T.,
Hata J.,
Sugiu K.,
Kusunoki H.,
Ito M.,
Tanaka S.,
Inoue K.,
Kawamura Y.,
Chayama K.,
Haruma K.
Publication year - 2005
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2005.02459.x
Subject(s) - medicine , helicobacter pylori , cancer , gastroenterology , atrophic gastritis , gastritis , prospective cohort study , atrophy , endoscopy , stomach , surgery
Summary Background : Eradication of Helicobacter pylori is expected to prevent the development of gastric cancer. However, gastric cancer is sometimes discovered after successful eradication of H. pylori . Aim : To conduct a prospective study to determine the clinical features of patients who underwent successful eradication and were later diagnosed with gastric cancer. Methods : A total of 1787 patients (1299 males and 488 females; mean age, 58.2 years; range: 15–84) who underwent successful eradication therapy between April 1994 and March 2001 were our study subjects. Results : Gastric cancer occurred at a rate of 1.1% (20 of 1787) during the follow‐up period. Gastric cancer comprises six of 105 (5.7%) with early gastric cancer after endoscopic resection, 12 of 575 (2.1%) with gastric ulcer and two of 453 (0.4%) with atrophic gastritis. Gastric cancer did not develop in any patient with duodenal ulcer. All patients with gastric cancer had baseline severe atrophic gastritis in the corpus. Conclusion : Careful endoscopic examination is necessary even after successful eradication of H. pylori in patients with early gastric cancer or gastric ulcer with severe mucosal atrophy in the corpus.