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New once‐daily, highly effective rescue triple therapy after multiple Helicobacter pylori treatment failures: a pilot study
Author(s) -
Coelho L. G. V.,
Moretzsohn L. D.,
Vieira W. L. S.,
Gallo M. A.,
Passos M. C. F.,
Cindr J. M.,
Cerqueira M. C.,
Vitiello L.,
Ribeiro M. L.,
Mendonça S.,
PedrazzoliJúnior J.,
Castro L. P.
Publication year - 2005
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2005.02370.x
Subject(s) - medicine , rabeprazole , levofloxacin , furazolidone , rapid urease test , helicobacter pylori , gastroenterology , breath test , urea breath test , nausea , amoxicillin , vomiting , surgery , gastritis , antibiotics , helicobacter pylori infection , microbiology and biotechnology , biology
Summary Background: Helicobacter pylori treatment failure is a growing problem in daily practice. Aim: To determine the efficacy of the combination of rabeprazole, levofloxacin and furazolidone as a rescue therapy. Methods: Duodenal ulcer patients previously submitted, without success, to at least two H. pylori treatment regimens were included. Gastroscopy (urease test, histological examination and culture) and 13 C‐urea breath test were performed. All patients received a combination of rabeprazole 20 mg, levofloxacin 500 mg and furazolidone 200 mg (two tablets) administered in a single dose in the morning for 10 days. Clinical examination and a new 13 C‐urea breath test were performed 90 days after therapy. Results: Twelve patients (eight females and four males), mean age 43 (30–58) years were included. Two patients failed to complete the treatment because of nausea and vomiting. Ten patients completed the study and took all the medications as advised. Culture was obtained in six patients: 100 and 83% of the samples were sensitive to furazolidone and levofloxacin, respectively. Per‐protocol and intention‐to‐treat eradication rates were 100 and 83% ( P = 0.019). Conclusions: the combination of rabeprazole, levofloxacin and furazolidone in a single daily dose for 10 days constitutes a highly‐effective and low‐cost alternative as a third‐line therapy in patients infected with H. pylori .