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Review article: orofacial granulomatosis
Author(s) -
Leão J. C.,
Hodgson T.,
Scully C.,
Porter S.
Publication year - 2004
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2004.02205.x
Subject(s) - medicine , etiology , sarcoidosis , dermatology , disease , systemic disease , biopsy , oral and maxillofacial pathology , pathology , dentistry
Summary Orofacial granulomatosis is an uncommon clinicopathological entity describing patients who have oral lesions characterized by persistent and/or recurrent labial enlargement, oral ulcers and a variety of other orofacial features, who on lesional biopsy have lymphoedema and non‐caseating granulomas. The aetiology of oral lesions with non‐caseating granulomas includes oral Crohn's disease (some patients with oral lesions will develop typical bowel symptoms of Crohn's disease in ensuing months to years), tooth‐associated infections, sarcoidosis and food or contact allergies. Treatment of orofacial granulomatosis is not reliably effective and may not be always necessary, although most patients do require some medical intervention.