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13 C‐ethanol breath test reveals impaired alcohol metabolism in patients with Helicobacter pylori infection
Author(s) -
Suzuki M.,
Maruyama K.,
Suzuki H.,
Tanaki S.,
Suzuki K.,
Ishii H.
Publication year - 2004
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2004.02020.x
Subject(s) - breath test , helicobacter pylori , cmax , ethanol , gastroenterology , alcohol , alcohol dehydrogenase , medicine , metabolism , ethanol metabolism , gastritis , excretion , feces , stomach , spirillaceae , pharmacokinetics , chemistry , microbiology and biotechnology , biology , biochemistry
Summary Background : The gastric mucosal alcohol dehydrogenase activity was reported to be reduced in subjects with Helicobacter pylori ‐associated chronic gastritis. However, the role of H. pylori infection in the metabolism of ingested ethanol has not been fully elucidated. Aim : To clarify whether H. pylori infection exerts any influence on the metabolism of small amounts of ethanol in humans. Subjects and methods : 13 C‐ethanol (100 μ L) diluted in 100 mL water was administered orally to 22 healthy volunteers before breakfast. Breath samples were then collected every 10 min for up to 60 min. The content of 13 CO 2 (‰) was analysed using a mass‐spectrometric method. The excretion rate of labelled CO 2 was analysed by calculation of the following mathematical parameters, i.e., T max , C max , and AUC 60 . Results : In H. pylori ‐negative controls ( n = 11), the T max , C max and AUC 60 were 0.47 ± 0.13, 19.1 ± 6.0 and 13.7 ± 4.5, respectively. The corresponding values were 0.53 ± 0.16 (n.s.) and 12.7 ± 4.8 ( P < 0.05) and 9.0 ± 3.6 ( P < 0.05), respectively, in subjects with H. pylori infection ( n = 11). Successful eradication of H. pylori was associated with significant increase of these parameters ( C max and AUC 60 , n = 6). Conclusions : The metabolism of small amounts of ethanol is attenuated in subjects with H. pylori infection.