Premium
Hypoacidity combined with high gastric juice nitrite induced by Helicobacter pylori infection is associated with gastric cancer
Author(s) -
Shiotani A.,
Iishi H.,
Uedo N.,
Higashino K.,
Kumamoto M.,
Nakae Y.,
Tatsuta M.
Publication year - 2004
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2004.01978.x
Subject(s) - gastroenterology , helicobacter pylori , pepsin , nitrite , medicine , cancer , gastritis , spirillaceae , stomach , chemistry , biochemistry , enzyme , organic chemistry , nitrate
Summary Background : In patients with Helicobacter pylori infection, the concentration of nitrite in gastric juice is elevated. The degree of elevation correlates with that of inflammation and H. pylori density. Aim : The aim of this study was to examine hypoacidity and high nitrite levels related to H. pylori infection in patients with gastric cancer. Methods : We studied 88 patients with more than one history of endoscopic mucosal resection (EMR) for early gastric cancer and 88 age‐matched controls. C oncentration of nitrite in gastric juice was measured by Griess reaction, and serum pepsinogen levels were measured by RIA. Results : Multiple malignant lesions were found in 20 of the 88 patients. Serum gastrin, gastric juice pH and nitrite levels in patients with gastric cancer were significantly higher and pepsinogen I and pepsinogen I/II significantly lower than in control subjects. Pepsinogen I level and I/II ratio were lower and gastric juice pH was higher in the protruded‐type group than in the depressed‐type group. Pepsinogen I and pepsinogen I/II were lower and gastric juice pH was higher in multiple than in single cases. Conclusions : Hypoacidity combined with high gastric juice nitrite induced by H. pylori infection is associated with the intestinal type of gastric cancer, especially protruded lesions.