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Inter‐digestive and post‐prandial antro‐pyloro‐duodenal motor activity in humans: effect of 5‐hydroxytryptamine 1 receptor agonism
Author(s) -
Calvert E. L.,
Whorwell P. J.,
Houghton L. A.
Publication year - 2004
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.2004.01901.x
Subject(s) - sumatriptan , migrating motor complex , pylorus , duodenum , antrum , medicine , endocrinology , motor activity , motility , agonist , antagonist , stomach , receptor , biology , genetics
Summary Background : Little is known about the effect of 5‐hydroxytryptamine 1 (5‐HT 1 ) receptor agonism on the co‐ordinated motor activity of the gastric antrum, pylorus and duodenum under fasting and fed conditions. Aim : To evaluate the effect of sumatriptan, a 5‐HT 1 agonist, on fasting and fed antro‐pyloro‐duodenal motility. Methods : In study 1, antro‐pyloro‐duodenal motility was recorded for two phase IIIs of the migrating motor complex and then, following either a subcutaneous injection of sumatriptan 6 mg or saline control, for at least one additional phase III in 11 healthy volunteers (21–36 years). In study 2, the post‐prandial motility was recorded for 3 h after either a subcutaneous injection of sumatriptan 6 mg or saline control in 10 healthy volunteers (18–36 years). Results : Sumatriptan prolonged the migrating motor complex cycle ( P = 0.009) by increasing the duration of phase II ( P = 0.02) but not phases I and III. Post‐prandially, sumatriptan reduced the activity index ( P = 0.017) by reducing the frequency of co‐ordinated motor activity involving the antrum and/or the duodenum ( P < 0.05). Conclusion : 5‐HT 1 receptor agonism increases the periodicity of the migrating motor complex and reduces the occurrence of post‐prandial co‐ordinated motor activity involving the gastric antrum, pylorus and duodenum.