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The effect of polyunsaturated phosphatidyl choline in the treatment of acute viral hepatitis
Author(s) -
GUAN R.,
HO K. Y.,
KANG J. Y.,
YAP I.,
GWEE K. A.,
TAN C. C.
Publication year - 1995
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1995.tb00441.x
Subject(s) - medicine , choline , polyunsaturated fatty acid , phosphatidyl choline , hepatitis , viral hepatitis , bilirubin , gastroenterology , eicosapentaenoic acid , randomized controlled trial , pharmacology , biochemistry , fatty acid , biology , phospholipid , membrane
SUMMARY Background : Polyunsaturated phosphatidyl choline is a preparation often advocated for diseases of the liver. Methods: In a randomized open controlled trial, a preparation of polyunsaturated phosphatidyl choline, at a dose of 900 mg orally daily, was given to 22 patients with acute viral hepatitis. A control group of 25 patients was not treated. Results : Serial serum bilirubin and alanine amino transferase levels were measured up to 12 weeks. The falls in their levels after 2 and 5 weeks, and the lengths of time to their normalization, were not significantly different in the treated group compared to the control group. Conclusion : The results indicated that polyunsaturated phosphatidyl choline had no beneficial effect on the course of acute viral hepatitis.