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The development of atrophic gastritis—Helicobacter pylori and the effects of acid suppressive therapy
Author(s) -
KUIPERS E. J.,
LEE A.,
KLINKENBERGKNOL E. C.,
MEUWISSEN S. G. M.
Publication year - 1995
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1995.tb00391.x
Subject(s) - helicobacter pylori , atrophic gastritis , gastroenterology , gastritis , medicine , intestinal metaplasia , gastric acid , helicobacter , secretion , stomach , atrophy , cancer , in vivo , spirillaceae , biology , microbiology and biotechnology
SUMMARY Helicobacter pylori is uniquely adapted to survival in the strongly acidic gastric lumen. In vitro , both acid and certain acid suppressors affect bacterial growth. In vivo , there is little evidence that acid suppressors have any effect on bacterial survival. In contrast, decrease of acid secretion quickly leads to a spreading of the bacterial infection throughout the body and fundus of the stomach, which is accompanied by an increase of the associated gastritis. Helicobacter pylori gastritis may, in a substantial number of infected subjects, ultimately lead to atrophy and intestinal metaplasia, conditions with an increased risk for gastric cancer. This review summarizes the data on the interrelation between Helicobacter pylori , gastric acid secretion and development of atrophic gastritis.