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Successful Helicobacter pylori eradication incorporating a one‐week antibiotic regimen
Author(s) -
HUDSON N.,
BRYDON W. G.,
EASTWOOD M. A.,
FERGUSON A.,
PALMER K. R.
Publication year - 1995
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1995.tb00350.x
Subject(s) - medicine , metronidazole , regimen , omeprazole , helicobacter pylori , tolerability , gastroenterology , pseudomembranous colitis , clarithromycin , antibiotics , amoxicillin , intention to treat analysis , surgery , randomized controlled trial , adverse effect , clostridium difficile , microbiology and biotechnology , biology
SUMMARY Background : The optimum regimen for the eradication of Helicobacter pylori remains unclear. The aim of this study was to determine the efficacy and tolerability of omeprazole 40 mg daily given for 2 weeks, plus amoxycillin 500 mg t.d.s. and metronidazole 400 mg t.d.s. given for the first 7 days, in the treatment of H. pylori associated peptic ulcer disease. Results : One hundred and thirty‐two consecutive patients with peptic ulcer disease were entered into the study (89 male, 41 female; median age 47 years; inter‐quartile range: 36–58 years). H. pylori was eradicated successfully in 109 of 130 patients (intention‐to‐treat: 83%; 95% confidence limits: 76–89%); per protocol: 85% (95% CI: 78–91%)). Ninety per cent of patients completed the full course of therapy. Only four patients (3%) stopped treatment as a result of side effects although these occurred in 41% of patients. One patient developed pseudomembranous colitis requiring hospital admission. Conclusion : Omeprazole combined with one week of treatment of amoxycillin and metronidazole is an effective and well tolerated Helicobacter eradication regimen. Occasional severe side effects remain a risk, even when the duration of antibiotic exposure is reduced.