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Studies of water movement across the gut using oral rehydration solutions in a rat perfusion model
Author(s) -
PILLAI G. V.,
BRUETON M. J.,
BURSTON D.,
SANDHU B. K.
Publication year - 1994
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1994.tb00330.x
Subject(s) - sodium , medicine , perfusion , absorption (acoustics) , oral administration , potassium , in vivo , absorption of water , oral rehydration therapy , food science , gastroenterology , zoology , chemistry , microbiology and biotechnology , population , biology , botany , physics , environmental health , organic chemistry , acoustics , health services
SUMMARY Aim: To measure water influx and efflux, as well as net water, sodium and potassium absorption from a range of oral rehydration solutions (ORS) in which the glucose content had been partially replaced with the amino acid leucine or with food supplements. Methods: A series of in vivo steady‐state perfusion studies in normal rat intestine. The oral rehydration solutions contained 60 or 90 mmol/L of sodium. The reference solution used was the World Health Organization (WHO) formula. Results: There was a significant negative correlation between the oral rehydration solution osmolality and net water absorption ( r =–0.722, P < 0.05). The highest net water absorption occurred using comminuted chicken supplemented oral rehydration solution containing 60 mmol/L sodium ( P < 0.001). This oral rehydration solution also showed a significant increase in the rate of influx of water ( P < 0.05) in comparison with the WHO formula containing 60 mmol/L sodium. Conclusion: This work provides further evidence that food‐based oral rehydration solutions, including non‐vegetable sources, may have a useful role to play in the management of patients with acute diarrhoea.