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Short report: interferon‐α decreases 14 C–aminopyrine breath test values in patients with chronic hepatitis C
Author(s) -
HORSMANS Y.,
BRENARD R.,
GEUBEL A. P.
Publication year - 1994
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1994.tb00301.x
Subject(s) - medicine , breath test , gastroenterology , interferon , hepatitis , liver function tests , chronic hepatitis , immunology , virus , helicobacter pylori
SUMMARY Objective : To investigate the effect of interferon‐ α on cytochrome P‐4 50 dependent microsomal function. Methods : The 14 C‐aminopyrine breath test was performed before, during and after a standard dose of interferon‐ α (3 units three times per week) was administered for at least six months (nine patients with chronic hepatitis C). Results : Mean aminopyrine breath test values obtained during therapy were significantly lower than either pre‐ or post‐treatment, the degree of reduction varying widely between individuals. Pre‐ and post‐treatment aminopyrine breath test values did not differ significantly. Conclusion : Interferon therapy is associated with a significant and transient inhibition of cytochrome P‐450 activity, which should be taken into account when prescribing concurrent therapy with drugs metabolized by this pathway.