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Short report: evaluation of Helicobacter pylori eradication with bismuth sucrlfate
Author(s) -
REIJERS M. H. E.,
NOACH L. A.,
TYTGAT G. N. J.
Publication year - 1994
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1994.tb00300.x
Subject(s) - sucralfate , medicine , helicobacter pylori , gastroenterology , bismuth , urea breath test , gastritis , spirillaceae , breath test , helicobacter pylori infection , materials science , metallurgy
SUMMARY Methods : In a pilot study we have evaluated the clinical efficacy of bismuth sucralfate to eradicate H. pylori . Ten consecutive patients with chronic dyspepsia and H. pylori associated gastritis were treated with bismuth sucralfate (220 mg bismuth per tablet, 4 tablets per day for 4 weeks). If a 14 C urea breath test immediately after the medication was negative, a gastroscopy was performed one month later to obtain biopsies for culture and histological examination. Results : Four patients experienced side effects. In none of the ten patients could eradication of H. pylori be demonstrated one month after treatment with bismuth sucralfate. Conclusion : Bismuth sucralfate is not effective for the treatment of H. pylori infection.