Premium
Phospholipase A 2 activity in gastric juice from patients with active and H. pylori‐eradicated healed duodenal ulcer
Author(s) -
BERSTAD K.,
SJÖDAHL R.,
BERSTAD A.
Publication year - 1994
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1994.tb00275.x
Subject(s) - gastroenterology , choline , medicine , phospholipase , helicobacter pylori , duodenal ulcer , spirillaceae , biochemistry , enzyme , gastritis , chemistry
SUMMARY Background: Despite the close association between gastric Helicobacter pylori infection and duodenal ulcer. little is known about how this organism may promote mucosal damage. A possibility might be that it produces, or induces the host to release, phospholipases that metabolize the protective layer of phospholipids Methods : Aimed at determination of phospholipase A 2 activity and the concentration of choline‐containing phospholipids in gastric juice, aspirates were collected during gastroscopy in 38 consecutive referrals with either active ( n = 19) or H. pylori‐eradicated healed duodenal ulcer ( n = 19). Results: Gastric juice phospholipase A 2 activity was 3.1 times higher in active than in healed duodenal ulcers (P = 0.03). Concurrently, the concentration of choline‐containing phospholipids in the group with active ulcers was less than half compared with the healed group (P = 0.02). Conclusion: The results indicate that phospholipase A 2 activity and the concentration of choline‐containing phospholipids in gastric juice are related to H. pylori status and duodenal ulcer disease.