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Comparison of pantoprazole and ranitidine in the treatment of acute duodenal ulcer
Author(s) -
JUDMAIER G.,
KOELZ H. R.
Publication year - 1994
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1994.tb00163.x
Subject(s) - ranitidine , medicine , pantoprazole , gastroenterology , duodenal ulcer , duodenum , omeprazole
SUMMARY Background: Pantoprazole is a new substituted benzimidazole that blocks the H + /K + ‐ATPase in the gastric mucosa and thus inhibits acid secretion. Methods : Efficacy and tolerability of pantoprazole (40 mg at breakfast) and ranitidine (300 mg at bedtime) in the treatment of uncomplicated acute duodenal ulcer were compared in a double‐blind, randomized multicentre trial. Results: Of 202 outpatients who entered the study, 185 terminated the treatment without violation of the protocol. After 2 weeks of treatment, healing rates (protocol correct) with pantoprazole and ranitidine were 81 and 53%, respectively ( P > 0.001), the corresponding results after 4 weeks were 97 and 83% ( P > 0.01). Pantoprazole was more effective with respect to symptom relief. Both treatments were well tolerated. Conclusion: Pantoprazole 40 mg at breakfast is superior to ranitidine 300 mg at bedtime in the short‐term treatment of acute, uncomplicated duodenal ulcer.