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Short report: smoking habits and the acquisition of metronidazole resistance in patients with Helicobacter pylori‐related gastritis
Author(s) -
WITTEMAN E. M.,
HOPMAN W. P. M.,
BECX M. C. J. M.,
DE KONING R. W.,
TYTGAT G. N. J.,
JANSSEN A. J. H. M.,
JANSEN J. B. M. J.
Publication year - 1993
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1993.tb00151.x
Subject(s) - metronidazole , medicine , helicobacter pylori , gastroenterology , gastritis , regimen , alcohol consumption , antrum , spirillaceae , stomach , antibiotics , alcohol , microbiology and biotechnology , biochemistry , chemistry , biology
SUMMARY Thirty‐three dyspeptic patients with colonization of Helicobacter pylorl in the gastric antrum were treated with tripotassium dicitrate bismuthate 120 mg q.d.s. for 28 days and metronidazole 250 mg q.d.s for 10 days starting on day 19. Five weeks after cessation of this treatment regimen H. pylori was eradicated in 23 patients. In 8 of the remaining 10 patients, H. pylori had become resistant to metronidazole. In this study resistance was significantly associated with smoking habits, but not with age, bacterial load, gastritis score or alcohol consumption.