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Does lansoprazole influence postprandial digestive function?
Author(s) -
VIDON N.,
DUTREUIL C.,
SCOULE J. C.,
DELCHIER J. C.
Publication year - 1993
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1993.tb00144.x
Subject(s) - postprandial , lansoprazole , gastric emptying , medicine , duodenum , gastroenterology , placebo , crossover study , gastric acid , proton pump inhibitor , endocrinology , meal , cholecystokinin , gastrointestinal hormone , stomach , omeprazole , peptide hormone , insulin , alternative medicine , pathology , receptor
SUMMARY The effects of a potent proton pump inhibitor on postprandial digestive functions were compared with those of a placebo in a double‐blind randomized crossover study. Six healthy male volunteers received 30 mg/day of lansoprazole or placebo for 7 days, with a wash‐out period of 14 days. As compared to placebo, lansoprazole induced a marked decrease of mean ± S.E.M. 3‐h gastric acid secretion from 46.8 ± 10.8 mmol to 10.9 ± 2.5 mmol ( P < 0.05), and a decrease of the volume of gastric contents emptying into the duodenum from 1043 ± 139 ml to 660 ± 87 ml ( P < 0.05). However, gastric emptying remained unchanged with meal gastric emptying half times of 66 ± 5 min and 67 ± 13 min, respectively. During the 3‐h postprandial period , duodenal lipase and chymotrypsin outputs were 366 ± 123 KIU and 56 ± 11 KIU with lansoprazole and 436 ± 119 KIU and 49 ± 8 KIU with placebo (N.S.). Bile acid outputs were 5.3 ± 0.7 mmol and 6.0 ± 1.0 mmol, respectively (N.S.) There was no change in kinetic profiles of biliarypancreatic secretion. We conclude that potent inhibition of gastric secretion by chronic administration of a proton pump inhibitor at usual therapeutic dose alters neither meal gastric emptying nor postprandial biliary‐pancreatic secretion.