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Effects of indomethacin on intragastric pH and meal‐stimulated serum gastrin secretion in rheumatoid arthritis patients
Author(s) -
JANSSEN M.,
BAAK L. C.,
JANSEN J. B. M. J.,
DIJKMANS B. A. C.,
VANDENBROUCKE J. P.,
LAMERS C. B. H. W.
Publication year - 1993
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1993.tb00112.x
Subject(s) - medicine , gastroenterology , placebo , rheumatoid arthritis , basal (medicine) , gastrin , gastritis , arthritis , peptic , helicobacter pylori , endocrinology , peptic ulcer , secretion , pathology , insulin , alternative medicine
SUMMARY The effects of oral indomethacin on intragastric pH and serum gastrin were investigated in rheumatoid arthritis patients. Nine patients (1 male, 8 female) without a history of peptic ulcer disease and 6 patients with a history of peptic ulcer disease (5 male, 1 female) were studied. To obviate Helicobacter pylori infection as a confounding factor, only patients with positive H. pylori serology were included. After a 5‐day period of placebo treatment and after a 5‐day period of indomethacin (50 mg t.d.s.; total dose 750 mg), 24‐h intragastric pH and basal and meal‐stimulated serum gastrin levels were measured in a double‐blind placebo controlled cross‐over study. There were no differences in the median 24‐h pH values between placebo and indomethacin irrespective of peptic ulcer disease history. Indomethacin resulted in a higher basal and stimulated gastrin response than placebo in patients with a history of peptic ulcer disease. The basal and incremental responses were lower in patients with a history of peptic ulcer disease than in patients without a history of peptic ulcer disease, both during indomethacin and placebo. The same basal and stimulated incremental serum gastrin responses were found during placebo and indomethacin treatment in patients without a history of peptic ulcer disease. No correlation was established between median 2‐h post‐prandial intragastric pH and post‐prandial incremental serum gastrin concentration. We conclude that indomethacin does not influence the intragastric pH of rheumatoid arthritis patients irrespective of history of peptic ulcer disease.