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Effect of sumatriptan, a new selective 5HT 1 ‐like agonist, on liquid gastric emptying in man
Author(s) -
HOUGHTON L. A.,
FOWLER P.,
KEENE O. N.,
READ N. W.
Publication year - 1992
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1992.tb00732.x
Subject(s) - sumatriptan , medicine , gastric emptying , agonist , 5 ht1 receptor , 5 ht receptor , gastroenterology , pharmacology , stomach , serotonin , receptor , metabotropic receptor
SUMMARY Paired studies were carried out on 12 healthy male subjects to compare the effect of intravenous doses of the 5‐HT 1 ‐like agonist sumatriptan (GR43175; 3 mg), 10 mg metoclopramide and saline control on the rate of gastric emptying of a radiolabelled liquid test‐meal. Intravenous administration of metoclopramide accelerated gastric emptying by decreasing the lag period, while intravenous administration of sumatriptan delayed gastric emptying by increasing the lag period. The observation that sumatriptan causes a delay in gastric emptying in normal healthy volunteers, but relieves nausea and vomiting during migraine attacks, suggests that sumatriptan may be acting via a central mechanism to relieve symptoms of nausea and vomiting associated with migraine.