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Comparison between a standard pancreatic supplement and a high enzyme preparation in cystic fibrosis
Author(s) -
MORRISON G.,
MORRISON J. M.,
REDMOND A. O. B.,
BYERS C. A.,
McCRACKEN K. J.,
DODGE J. A.,
GUILFORDS S. A.,
BOWDEN M. W.
Publication year - 1992
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1992.tb00569.x
Subject(s) - medicine , lipase , cystic fibrosis , absorption (acoustics) , enzyme , protease , gastroenterology , meal , endocrinology , food science , biochemistry , chemistry , physics , acoustics
SUMMARY This study compared the relative effectiveness of a standard pancreatic enzyme supplement (‘Creon’, Duphar) and a new preparation (‘Pancrease HL’, Cilag) containing about 3 times the lipase and more than 5 times the protease activity. Capsule dosage was adjusted to a ratio of approximately 3:1. Fat balances showed that absorption of fat did not change significantly on conversion to the new high‐lipase product, and the coefficient of absorption of total energy was similarly maintained. The coefficient of protein absorption was significantly enhanced with the high enzyme preparation ( P < 0.01), which may explain the reported subjective improvement in stool odour. No adverse effects were recorded. Patient acceptability of the new compound was high; the great reduction in the number of capsules required at each meal was cited by all patients as the reason for their preference.