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Short report: the effect of ranitidine on the post‐prandial absorption of a low dose of alcohol
Author(s) -
FRASER A. G.,
HUDSON M.,
SAWYERR A. M.,
ROSALKI S. B.,
POUNDER R. E.
Publication year - 1992
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1992.tb00270.x
Subject(s) - ranitidine , alcohol , placebo , evening , medicine , dosing , ethanol , absorption (acoustics) , meal , morning , pharmacokinetics , anesthesia , chemistry , biochemistry , physics , alternative medicine , pathology , astronomy , acoustics
SUMMARY Twenty healthy male subjects were studied twice using a double‐blind, randomized placebo controlled, cross‐over study design. Alcohol absorption (integrated 2‐h plasma alcohol concentration, peak plasma alcohol concentration, and time to reach peak concentration) was measured after 8 daily doses of either placebo or 300 mg ranitidine. They were given alcohol, 0.15 g/kg of body weight by month after an evening meal. Compared with placebo, there was a trend towards higher integrated 2‐h plasma alcohol concentrations (3.17 and 3.89 mg. h/dL, respectively, P = 0.07), and a statistically significant increase in mean peak plasma alcohol concentration after dosing with ranitidine (4.92 and 6.47 mg/dL, respectively, P = 0.05).