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Effects on the rat oxyntic mucosa of the histamine 2 ‐antagonist loxtidine and the H + , K + ‐ATPase inhibitor omepvazole
Author(s) -
BRENNA E.,
WALDUM H. L.,
SANDVIK A. K.,
SØGNEN B. SCHULZE,
KRISTENSEN A.
Publication year - 1992
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1992.tb00055.x
Subject(s) - omeprazole , histamine , enterochromaffin like cell , parietal cell , medicine , endocrinology , histamine h2 receptor , gastrin , stomach , gastric mucosa , antagonist , proton pump inhibitor , gastric acid , receptor , secretion
SUMMARY The present study examined whether histamine could affect the growth of the enterochromaffin‐like (ECL) cell and the parietal cell. The effects of the unsurmountable histamine H 2 ‐receptor antagonist loxtidine (80 mg/kg) and the H + , K + ‐ATPase inhibitor omeprazole (100 μmol/kg) were compared in female Sprague‐Dawley rats. Both drugs were given by gavage once daily for 3 months. Omeprazole induced a more pronounced and sustained hypergastrinaemia than loxtidine. In spite of marked hypergastrinaemia during most of the day, even in the loxtidine‐treated rats, the weights of the stomach and oxyntic mucosa were elevated only in the omeprazole‐treated rats. The ECL cell density was slightly higher in the loxtidine‐ than in the omeprazole‐treated rats. Both treatments elevated the gastrin‐stimulated histamine release from the vascularly perfused stomach. The parietal cell density was unaffected by omeprazole treatment, whereas it tended to be reduced in the loxtidine‐treated rats. Simultaneous administration of loxtidine and omeprazole reduced the sustained hypergastrinaemia induced by omeprazole given alone. The present study may indicate that histamine inhibits the growth of the ECL cell, but further studies are needed to elucidate if histamine has any trophic effect on the parietal cells.