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Review article: the histamine H 3 ‐receptor: a novel prejunctional receptor regulating gastrointestinal function
Author(s) -
BERTACCINI G.,
CORUZZI G.,
POLI E.
Publication year - 1991
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1991.tb00526.x
Subject(s) - thioperamide , cholinergic , histamine h3 receptor , histamine , myenteric plexus , receptor , endocrinology , medicine , histamine receptor , enteric nervous system , agonist , histamine h2 receptor , neuroscience , biology , antagonist , immunohistochemistry
SUMMARY This review examines the evidence for the existence in the gastrointestinal tract of a new subtype (H 3 ) of histamine receptors, previously described in the central nervous system. Study of these receptors is facilitated by the availability of the highly selective agonist (R) α ‐methylhistamine and the selective antagonist, thioperamide. H 3 ‐receptors seem to exert negative control on gastric acid secretion evoked by indirect cholinergic stimuli: their localization is unclear but it seems to be outside the parietal cell. H 3 ‐receptors also seem to be located on cholinergic and non‐adrenergic non‐cholinergic (NANC) neurones of the myenteric plexus, where they negatively control the release of neurotransmitters.