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Cisapride in the treatment of post‐operative ileus
Author(s) -
HALLERBÄCK B.,
BERGMAN B.,
BONG H.,
EKSTRÖM P.,
GLISE H.,
LUNDGREN K.,
RISBERG O.
Publication year - 1991
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1991.tb00519.x
Subject(s) - cisapride , medicine , placebo , ileus , elective surgery , placebo group , surgery , colorectal surgery , postoperative ileus , anesthesia , randomized controlled trial , gastroenterology , abdominal surgery , alternative medicine , pathology
SUMMARY The effect of cisapride on duration of post‐operative ileus after surgery was investigated in a randomized, double‐blind, placebo‐controlled study. Patients undergoing elective upper gastrointestinal ( n = 47) or colonic ( n = 22) surgery were pre‐operatively randomly allocated to treatment with either cisapride 30 mg t.d.s., by rectal administration, or placebo. Treatment started exactly 48 h after surgery if the patient at this time had not passed stool. Time to passage of first stool after surgery was estimated. Mean time to passage of stool was 85 (32) h (s.d.) for cisapridetreated and 91 (43) h for placebo‐treated patients. No difference between the treatment groups was noted. Treatment with cisapride did not shorten the duration of postoperative ileus after either upper gastrointestinal or colonic surgery.