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Eradication of Helicobacter pylori abolishes 24‐hour hypergastrinaemia: a prospective study in healthy subjects
Author(s) -
PREWETT E. J.,
SMITH J. T. L.,
NWOKOLO C. U.,
HUDSON M.,
SAWYERR A. M.,
POUNDER R. E.
Publication year - 1991
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1991.tb00029.x
Subject(s) - medicine , helicobacter pylori , gastrin , gastroenterology , rapid urease test , spirillaceae , metronidazole , prospective cohort study , urea breath test , antrum , gastritis , stomach , breath test , gastric mucosa , biopsy , helicobacter pylori infection , antibiotics , biology , microbiology and biotechnology , secretion
SUMMARY In a prospective study, eight young healthy subjects (five with an active H. pylori infection in the antral mucosa) were treated with a course of tripotassium dicitrato bismuthate, amoxycillin and metronidazole. The triple therapy eradicated infection when assessed 20–24 weeks later by antral biopsy (urease, histology, and 13 C urea breath test [4 out of 5 subjects]). Twenty‐four hour intragastric acidity and plasma gastrin concentration were measured before treatment, and 4–6 weeks and 20–24 weeks post‐treatment. Treatment did not affect acidity in either the H. pylori ‐positive or H. pylori ‐negative groups, nor did it affect the plasma gastrin profile in the H. pylori ‐negative group. Eradication of H. pylori infection in five subjects caused a drop of the median integrated 24‐hour plasma gastrin concentration from 558 pmol. h/L before treatment to 307 and 289 pmol.h/L at 4–6 and 20–24 weeks post‐treatment, respectively. It is concluded that H. pylori infection is associated with 24‐hour hypergastrinaemia, and that in apparently healthy subjects normal gastric physiology can be restored by eradication of the infection.