Premium
Assessment of water and solute absorption from experimental hypotonic and established oral rehydration solutions in secreting rat intestine
Author(s) -
HUNT J. B.,
CARNABY S.,
FARTHING M. J. G.
Publication year - 1991
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1991.tb00028.x
Subject(s) - tonicity , medicine , absorption (acoustics) , materials science , composite material
SUMMARY Water and solute absorption from three experimental hypotonic oral rehydration solutions (HYPO‐ORS; sodium 45, 60 and 75 mmol/L, glucose 90 mmol/L), the World Health Organization recommended ORS (WHO‐ORS; sodium 90 mmol/L, glucose 111 mmol/L), and the British National Formulary recommended ORS (BNF‐ORS; sodium 35 mmol/L, glucose 200 mmol/L), have been assessed by perfusion studies in cholera toxin‐induced secreting rat intestine. Net water absorption was greatest from the most hypotonic solution (HYPO‐45; P < 0.05). UK‐ORS prevented net water secretion and WHO‐ORS promoted moderate net water absorption. Net sodium secretion was seen with all solutions but was least from WHO‐ORS and greatest with BNF‐ORS ( P < 0.01). Glucose absorption was similar from BNF‐ORS, WHO‐ORS and HYPO‐45 and in each case was greater than glucose absorption from HYPO‐60 and HYPO‐75 ( P < 0.05). These results suggest that net water and sodium absorption from ORS may be enhanced if osmolality is reduced by decreasing the glucose content.