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The effect of colestipol dose on postprandial serum bile acid concentration: assessment by an enzymic bioluminescence procedure
Author(s) -
FLEISHAKER J. C.,
ROSSI S. S.,
SMITH R. B.,
WELSHMAN I. R.,
DAEI F.,
ANGELLOTTI M. A.,
HOFMANN A. F.
Publication year - 1990
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1990.tb00510.x
Subject(s) - postprandial , medicine , bile acid , endocrinology , asymptomatic , placebo , triglyceride , gastroenterology , cholesterol , pathology , alternative medicine , insulin
SUMMARY A dose‐response study was performed with three doses of colestipol, using postprandial serum bile acid levels to assess bile acid sequestering activity in 40 volunteers with asymptomatic hyperlipidaemia. Subjects who entered the study had total serum cholesterol concentrations greater than 220 mg/dl and triglyceride concentrations less than 200 mg/dl. They were randomly assigned to one of four parallel treatment groups: ( a ) placebo b.d., colestipol (as Colestid hydrochloride granules) 2.5 g b.d., ( c ) colestipol 5 g b.d., and ( d ) colestipol 7.5 g b.d. Subjects were maintained on a constant repeating solid diet throughout the 6‐day study period, and colestipol was ingested 30 min before breakfast and dinner. No drug was administered on Days 1–3; baseline (pre‐treatment) serum bile acid concentration profiles were determined on Day 3. The above treatments were given on Days 4–6, and total serum bile acid