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The absorption of bismuth and salicylate from oral doses of Pepto‐Bismol (bismuth salicylate)
Author(s) -
NWOKOLO C U.,
MISTRY P.,
POUNDER R. E.
Publication year - 1990
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1990.tb00461.x
Subject(s) - bismuth , medicine , absorption (acoustics) , pharmacology , chemistry , materials science , organic chemistry , composite material
SUMMARY Plasma bismuth and plasma salicylate concentrations were measured before and after three 30‐ml oral doses of bismuth salicylate (Pepto‐Bismol liquid) in 10 fasting healthy subjects. From 0 to 120 min following the first dose of bismuth salicylate, the plasma bismuth concentration was less than 1 ng/ml. The peak median plasma bismuth concentration was at + 240 min (1.7 ng/ml; range 0.8–5.3 ng/ml). Salicylate appeared in the plasma of all subjects at + 30 min, and it reached a peak at + 120 min (median 61 mg/L; range 46–104 mg/L). The study demonstrates that, despite rapid and substantial absorption of salicylate, there is negligible absorption of bismuth into the bloodstream from standard oral doses of bismuth salicylate.