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The effect of enprostil on duodeno‐jejunal motility in man
Author(s) -
DUCROTTE P.,
PARENT B.,
MASLIAH C.,
JOUBERT M.,
COLIN R.,
DENIS P.
Publication year - 1990
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1990.tb00451.x
Subject(s) - medicine , placebo , crossover study , dosing , motility , gastroenterology , oral administration , endocrinology , biology , alternative medicine , pathology , genetics
SUMMARY Motor changes could be involved in the pathogenesis of diarrhoea that complicates the treatment of ulcer disease by prostaglandins. Our aim was to assess the effect of enprostil, a synthetic analogue of PGE 2 , on duodeno‐jejunal motility. During this randomized double‐blind crossover study, two manometric recordings, each lasting 20 h (12.00‐08.00 hours), were carried out during dosing with 35 μg enprostil b.d. or placebo (eight volunteers: part 1), or during dosing with 35 or 70 μg enprostil b.d. (nine volunteers: part 2). Subjects were only allowed a standard dinner at 18.00 hours. During fasting, in part 1, the number of phase 3 activity patterns (PIIIs) was higher with enprostil than with placebo ( P < 0.01), without any difference in their characteristics; the overall duration of phase 1 activity was longer with enprostil than with placebo ( P < 0.01). In part 2, during fasting the number and characteristics of the PIIIs were not different, but there was a dose‐related increase in PI, and decrease in PII activity. Fed motor patterns did not differ between the two doses of enprostil.