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Rapid intravenous low‐dose diazepam as sedation for upper gastrointestinal endoscopy
Author(s) -
SWAIN D. G.,
ELLIS D. J.,
BRADBY H.
Publication year - 1990
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1990.tb00447.x
Subject(s) - medicine , sedation , diazepam , endoscopy , intravenous sedation , upper gastrointestinal endoscopy , anesthesia , surgery
SUMMARY One hundred patients for endoscopy, aged, between 18 and 74 years were randomly allocated to two equal groups. Group A received 10 mg diazepam intravenously rapidly over 2–4 s; Group B received diazepam intravenously over 1–2 min, titrated to provide a satisfactory level of sedation (mean dose 15.9 mg). Patient co‐operation during endoscopy was similar in both groups, but one patient in Group A developed respiratory depression. Tests of psychomotor function after endoscopy showed greater impairment 30 min following injection for Group B, compared with Group A ( P < 0.02). Total or partial amnesia for endoscopy was present in 62% of Group A, and 90% in Group B ( P < 0.005). However, postal follow‐up showed that endoscopy was acceptable to 96% of Group A and 98% of Group B. Delayed sedation later in the day was reported by 26% of Group A compared with 48% of Group B.