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Galanin: hydrokinetic action on salivary glands in man
Author(s) -
BAUER F. E.,
GHATEI M. A.,
ZINTEL A.,
BLOOM S. R.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00252.x
Subject(s) - galanin , saliva , endocrinology , medicine , postprandial , bicarbonate , saline , amylase , neuropeptide , sodium , chemistry , biochemistry , insulin , enzyme , receptor , organic chemistry
SUMMARY Galanin was infused intravenously into eight healthy volunteers at a dose of 40 pmol kg −1 min −1 for 1 h to investigate the pharmacological effects of this peptide on the postprandial sialagogical response in man. Galanin significantly increased the salivary volume and the saliva output of sodium, chloride and bicarbonate compared to control saline infusion, but had no effect on the output of potassium and α‐amylase. An increase in salivary pH was also observed. The increase in salivary volume may indicate a physiological role of galanin in the control of salivary secretion.