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Review article: mechanisms of drug release from tablets and capsules. 2. Dissolution
Author(s) -
MELIA C. D.,
DAVIS S. S.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00243.x
Subject(s) - dissolution , bioavailability , drug , pharmacology , dosage form , medicine , solubility , dissolution testing , oral administration , chemistry , biopharmaceutics classification system , organic chemistry
SUMMARY Optimal drug dissolution is crucial to the success of oral drug therapy. Slow dissolution has frequently been correlated with poor or erratic performance of oral dosage forms in vivo , and drugs of low aqueous solubility provide a major challenge to the designer of modern oral dosage forms. In this second of two reviews, we briefly describe the physical process of dissolution, the principal factors controlling drug dissolution from tablets and capsules, and the strategies that are utilized by pharmaceutical scientists to enhance drug dissolution of orally administered drugs. Dissolution, Tablets, Drug release, Bioavailability.