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A pilot study of thymus extract in chronic non‐A, non‐B hepatitis
Author(s) -
CIVEIRA M. P.,
CASTILLA A.,
MORTE S.,
SERRANO M.,
PRIETO J.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00227.x
Subject(s) - medicine , immunity , cellular immunity , chronic hepatitis , immunology , hepatitis , chronic liver disease , immune system , gastroenterology , virus , cirrhosis
SUMMARY In previous studies it has been suggested that activation of cellular immunity may have a role in controlling the activity of chronic non‐A, non‐B liver disease. We conducted a pilot study of therapy with a bovine thymus extract for 6 weeks in 15 consecutive patients with chronic non‐A, non‐B hepatitis, most of them sporadic cases. Treatment induced immunomodulation, and in five patients a significant but transient diminution in aminotransferase levels was observed associated with increments in several parameters of cellular immunity. This suggests that a longer administration of this or other related compounds, or treatment with a more potent immunomodulating agent, might be effective in these patients.