Premium
A comparison of metoclopramide and trimebutine on small bowel motility in humans
Author(s) -
GRANDJOUAN S.,
CHAUSSADE S.,
COUTURIER D.,
THIERMANDUFFAUD D.,
HENRY J. F.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00226.x
Subject(s) - metoclopramide , motility , motilin , medicine , endocrinology , anesthesia , pharmacology , biology , vomiting , genetics
SUMMARY Trimebutine maleate and metoclopramide increase small bowel motility. The present manometric study of the human normal interdigestive duodeno‐jejunal motility demonstrated two different pharmacological effects in 15 healthy volunteers. Trimebutine constantly induced a premature phase 3 activity (0.81 ± 0.4 min after a 100‐mg intravenous injection) with patterns similar to spontaneous phase 3. Metoclopramide increased the motility index (contractile activity) during phase 2 without inducing a premature phase 3. No significant variations in plasma motilin concentration were noticed after either trimebutine or metoclopramide. The pancreatic polypeptide concentration rose significantly after metoclopramide injection.