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The effect of secretin on sodium ion absorption by the isolated human gallbladder
Author(s) -
JACYNA M. R.,
ROSS P. E.,
HOPWOOD D.,
BOUCHIER I. A. D.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00216.x
Subject(s) - secretin , gallbladder , medicine , endocrinology , sodium , ussing chamber , flux (metallurgy) , epithelium , absorption (acoustics) , cholecystectomy , chemistry , secretion , pathology , materials science , organic chemistry , composite material
SUMMARY Sodium ion (Na + ) transport, a principal function of the gallbladder epithelium, was studied by measuring the flux of 22 Na across isolated human gallbladder mucosa maintained in a modified‘Ussing’flux chamber. Tissue was obtained from cholecystectomy specimens in symptomatic patients with cholelithiasis. Out of 26 gallbladders studied, 13 had a net Na + flux from mucosa to serosa which indicated active Na + absorption. The hormone secretin, when added to the serosal fluid, reversed the direction of net flux in these gallbladders and caused a secretion of Na + from serosa to mucosa. These results suggest that secretin may be involved in the physiological regulation of fluid transport in the human gallbladder, and also suggest a possible role for this hormone in gallbladder emptying.