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A single night‐time dose of famotidine is equivalent to ranitidine in decreasing 24‐hour gastric acidity in asymptomatic duodenal ulcer subjects
Author(s) -
THOMSON A. B. R.,
PINCHBECK B. R.,
KIRDEIKIS J.,
ZUK L.,
MARRIAGE B.,
PRAT A.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00206.x
Subject(s) - famotidine , ranitidine , medicine , asymptomatic , gastroenterology , placebo , gastrin , gastric acid , duodenal ulcer , stomach , endocrinology , alternative medicine , pathology , secretion
SUMMARY Six asymptomatic, non‐smoking men with endoscopically proven duodenal ulcer disease received single nocturnal doses of placebo, 40 mg famotidine and 300 mg ranitidine each for 1 week prior to serial measurement of pH, peptic activity and serum gastrin concentrations over 24 h and of acid output. The intragastric pH fluctuated between 1.53 and 5.07 when subjects were given placebo but within 2 h of taking famotidine or ranitidine it rose to 5.57 or higher; the effect lasted for 12 h from midnight. Peptic activity fell during famotidine and ranitidine treatment and the decline was somewhat greater 8–15 h after using famotidine. Serum gastrin levels did not change materially with any treatment. The study shows the equivalent effect of standard bed‐time doses of famotidine and ranitidine on intragastric pH, acid output and serum gastrin concentrations in asymptomatic men with duodenal ulcer disease.