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Review article: a role for gastrointestinal prokinetic agents in the treatment of reflux oesophagitis?
Author(s) -
VERLINDEN M.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00197.x
Subject(s) - domperidone , cisapride , metoclopramide , medicine , gastroenterology , reflux , disease , pathogenesis , prokinetic agent , vomiting , dopamine
SUMMARY Gastro‐oesophageal reflux disease may result from a host of factors. Medical therapy has largely been aimed at neutralizing acid or decreasing acid production but improvement of upper‐gastrointestinal motility may prove to be a valuable treatment modality as well. This paper reviews the current state of knowledge of the pathogenesis of reflux disease and concentrates upon promotility treatment with domperidone, metoclopramide and cisapride.