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Effect of 10 mg and 20 mg omeprazole daily on duodenal ulcer: double‐blind comparative trial
Author(s) -
LAURITSEN K.,
ANDERSEN B. N.,
HAVELUND T.,
LAURSEN L. S.,
HANSEN J.,
ERIKSEN J.,
JØRGENSEN T.,
RASKMADSEN J.
Publication year - 1989
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1989.tb00191.x
Subject(s) - omeprazole , medicine , morning , gastroenterology , double blind , duodenal ulcer , surgery , anesthesia , placebo , alternative medicine , pathology
SUMMARY One‐hundred and seventy‐one patients with endoscopically proven duodenal ulcers were allocated at random to double‐blind treatment with 10 or 20 mg of omeprazole in the morning for up to 4 weeks. Patients completed the study if ulcer healing and pain relief had occurred at 2 weeks. A total of 155 patients completed the trial. Patients treated with 20 mg of omeprazole daily responded significantly more rapidly than those treated with 10 mg of omeprazole daily ( P < 0.001; Cochran‐Mantel‐Haenszel test covering both time points), cumulative healing rates at 2 and 4 weeks were 74% (58/78) and 91% (71/78), respectively. The corresponding rates in the group treated with 10 mg daily were 48% (39/81) and 75% (58/77). Pain relief was again more pronounced during treatment with the larger dose ( P < 0.05; stratified Wilcoxon test). No major clinical or biochemical side effects were noted. An omeprazole dose of 20 mg daily is preferable to a lower dose for the treatment of duodenal ulcer disease in the short term.