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Mechanisms of NSAID‐induced gastrointestinal mucosal injury: a basis for preventing ulceration and symptoms from these agents
Author(s) -
RAINSFORD K. D.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00764.x
Subject(s) - medicine , gastroenterology , mucosal lesions , dermatology
SUMMARY Concepts are reviewed of the effects of anti‐ulcer agents in counteracting the biochemical and cellular pathology of gastrointestinal injury by non‐steroidal anti‐inflammatory drugs (NSAIDs). While some measure of control of NSAID‐induced mucosal damage is achieved in the upper gastrointestinal tract by the currently available anti‐ulcer drugs, none can effectively counteract the major biochemical changes induced by NSAIDs. Some experimental approaches, which have been developed from recent studies in laboratory animals, are considered as a possible basis towards developing improvements in preventive procedures against NSAID‐induced gastrointestinal injury in man.