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The timing of evening meal and ranitidine administration—effects on patterns of 24 hour intragastric acidity
Author(s) -
ORR W. C.,
FINN A. L.,
ALLEN M.,
ROBINSON M. G.,
WILSON T.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00729.x
Subject(s) - ranitidine , medicine , ingestion , evening , meal , crossover study , morning , histamine h2 receptor , anesthesia , antagonist , physics , alternative medicine , receptor , pathology , astronomy , placebo
SUMMARY Intragastric pH‐metry was utilized to assess the effect of the time of meal ingestion and ranitidine administration on 24‐h intragastric acidity. Twelve volunteers with a documented history of duodenal ulcer were studied in a four‐way crossover design. Subjects randomly received ranitidine at 18.00 and 22.00 hours, with and without food. Serial blood samples were collected and analysed for ranitidine by high pressure liquid chromatography. Over the interval of 18.00–0.700 hours, the mean hydrogen‐ion activity was significantly lower with the 18.00 hour dose than with the 22.00 hour dose ( P ≤ 0.05). There were no differences between the four treatments in median pH or mean hydrogen‐ion activity over the 23‐h study interval. There were no differences between treatments in peak ranitidine concentrations, time to peak concentration, area under the serum‐concentration time curve or elimination half‐life.