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Inhibitory effect of isoprenaline on gastric acid secretion in the rat. The role of endogenous histamine
Author(s) -
HEYLINGS J. R.,
REDFERN J. S.,
FELDMAN M.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00715.x
Subject(s) - histamine , isoprenaline , pentagastrin , gastrin , endocrinology , medicine , gastric acid , secretion , endogeny , chemistry , inhibitory postsynaptic potential , stimulation
SUMMARY In dogs beta‐adrenoreceptor agonists inhibit gastric acid secretion stimulated by exogenous gastrin to a much greater extent than acid secretion stimulated by exogenous histamine. One possible explanation for this observation is that endogenous histamine is important in gastrin‐mediated acid secretion and that isoprenaline and related beta‐adrenoreceptor agonists block gastric mucosal histamine release. This possibility was tested in the present study in gastric lumen‐perfused anaesthetized rats. Intravenous infusion of isoprenaline (12 μg kg −1 h −1 ) inhibited maximal, pentagastrin‐stimulated acid output by 50–70% (P < 0.01), but had no significant inhibitory effect on the maximal acid secretory response to histamine. In contrast to its inhibitory effect on gastrin‐stimulated acid output, isoproterenol had no effect on gastric histamine output during pentagastrin infusion. We conclude that isoprenaline selectively inhibits gastrin‐stimulated acid secretion in the rat, as in the dog, and by a mechanism other than inhibiting gastric histamine release.