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Review: the pharmacological control of variceal bleeding
Author(s) -
FREEMAN J. G.,
RECORD C. O.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00712.x
Subject(s) - medicine , vasopressin , portal hypertension , somatostatin , hemodynamics , vasodilation , portal venous pressure , anesthesia , intensive care medicine , cirrhosis
SUMMARY The haemodynamic effects and clinical uses of drugs used in the management of patients with oesophageal variceal bleeding are reviewed. Vasoconstrictor agents (vasopressin, teripressin) alone or in combination with nitrates continue to be used for acute bleeding episodes, while somatostatin is an alternative. Alpha‐ and beta‐adrenergic blocking drugs and vasodilators which lead to a sustained decrease in portal pressure can be used for the prevention of bleeding episodes, but despite numerous studies the pharmacological treatment of variceal bleeding remains controversial.