Premium
Haemodynamic responses to 1.25 and 2 mg of terlipressin intravenously in man
Author(s) -
FREEMAN I. G.,
BARTON J. R.,
RECORD C. O.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00709.x
Subject(s) - terlipressin , medicine , hemodynamics , bolus (digestion) , blood pressure , portal venous pressure , anesthesia , mean arterial pressure , portal hypertension , adverse effect , cirrhosis , heart rate , hepatorenal syndrome
SUMMARY The systemic and hepatic haemodynamic effects following terlipressin (Glypressin) administration were studied. Bolus intravenous injections of 1.25 and 2 mg significantly decreased wedged hepatic vein pressure gradient by 29% and 31%, respectively. With each dose there was a small increase in mean arterial blood pressure but after 1.25 mg of terlipressin, estimated hepatic blood flow fell by only 11% (not significant) compared to 24% after 2 mg, while the cardiac index fell by 12% compared to 29%. The adverse haemodynamic effects of terlipressin were diminished by a decrease in dosage, without any alteration in the beneficial effect of the drug upon portal pressure. Whether the smaller dose will be effective in arresting variceal haemorrhage remains to be determined.