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Effect of low‐dose omeprazole on gastric acid secretion in duodenal ulcer patients
Author(s) -
McLAUCHLAN G.,
CREAN G. P.,
McCOLL K. E. L.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00696.x
Subject(s) - omeprazole , dosing , medicine , basal (medicine) , pentagastrin , gastric acid , gastroenterology , duodenal ulcer , dose–response relationship , endocrinology , stomach , insulin
SUMMARY The effect of 7 days of oral dosing with 5 mg day −1 and 20 mg day −1 omeprazole on basal and pentagastrin‐stimulated gastric acid output was studied in nine duodenal ulcer patients. Basal acid output measured 5–6 h post‐dosing was decreased by a mean of 75% on 5 mg omeprazole and by 90% on 20 mg omeprazole ( P < 0.05 and P < 0.01, respectively). Peak acid output measured 6–7 h post‐dosing was decreased by a mean of 75% on 5 mg omeprazole and 90% on 20 mg omeprazole ( P < 0.01 for each). There was a wide interindividual variation in response to the 5 mg dose, with five of the nine patients having more than 90% inhibition of peak acid output, but two patients having less than 40% inhibition. This unpredictable response to daily low‐dose omeprazole therapy makes it unsuitable for maintenance treatment.