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Prophylaxis of aspirin‐induced gastric mucosal bleeding with ranitidine
Author(s) -
HAWKEY C. J.,
SOMERVILLE K. W.,
MARSHALL S.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00694.x
Subject(s) - ranitidine , aspirin , medicine , gastroenterology , gastric mucosa , stomach , dosing , anesthesia , pharmacology
SUMMARY The ability of ranitidine to protect the human gastric mucosa against aspirin‐induced damage was investigated by timed measurements of blood loss collected by gastric washing. Ranitidine (150 mg) 1 h or 5 h before 900 mg aspirin (5 doses of each) over 48 h reduced subsequent mean bleeding from 7.7 μi/10 min to 2.6 μl/10 min or 3.4 μl/10 min, respectively. Both regimens were antisecretory at the time of aspirin administration, as judged by a rise in the pH of the aspirated washings. The prolonged protection against aspirin‐induced bleeding achieved with twice daily dosing with ranitidine has dinical potential in the management of patients taking anti‐inflammatory drugs.