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The effect of dietary fatty acids on the gastric production of prostaglandins and aspirininduced injury
Author(s) -
PRICHARD P.,
BROWN G.,
BHASKAR N.,
HAWKEY C.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00686.x
Subject(s) - evening primrose oil , aspirin , medicine , gamma linolenic acid , evening , evening primrose , crossover study , gastroenterology , fatty acid , traditional medicine , biochemistry , polyunsaturated fatty acid , chemistry , pathology , physics , alternative medicine , astronomy , placebo
SUMMARY We have investigated in man the effect of dietary supplementation with evening primrose oil (linoleic acid 72%, gamma‐linolenic acid 9%) on gastric immunoreactive PGE 2 release and aspirin‐induced mucosal injury. Twenty healthy volunteers received in a randomized crossover evening primrose oil (2 g b.d.) and olive oil (control) for 2 weeks each. During the last 48 hours of each period, five doses of aspirin 900 mg were taken. In gastric washings on day 7, evening primrose oil had enhanced immunoreactive PGE 2 release from a mean of 38 ng/30 min (olive oil) to 80 ng/30 min ( P < 0.05). This, however, was not able to protect against aspirin‐induced gastric blood loss which rose from a mean (95% confidence limits) of 1.3 (0.7–2.1) μl 10 min —1 (evening primrose oil day 7) to 9.4 (5.4–16.5) μl 10 min —1 (day 14). Although not effective against aspirin, similar dietary supplementation might assist in preventing peptic ulcer recurrence.