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Review: interactions between H 2 ‐antagonists and non‐steroidal anti‐inflammatory drugs
Author(s) -
HOWDEN C. W.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00676.x
Subject(s) - medicine , pharmacokinetics , antagonist , pharmacology , pharmacodynamics , receptor
SUMMARY Non‐steroidal anti‐inflammatory drugs (NSAIDs) are being prescribed increasingly with an H 2 ‐antagonist. This article reviews those published studies which have examined the potential for pharmacokinetic and, where appropriate, pharmacodynamic interactions between these classes of drugs. Studies involving the administration of a single dose of a NSAID to young healthy volunteers are of limited relevance in establishing the likely effect of an H 2 ‐antagonist on the blood concentrations of an NSAID in patients. Appropriate studies are those which will examine the effects of H 2 ‐antagonists on the steady‐state pharmacokinetics of NSAIDs in patients with inflammatory joint diseases. More of such studies are required, particularly involving elderly patients.