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Pharmacological manipulation of adynamic ileus: controlled randomized double‐blind study of ceruletide on intestinal motor activity after elective abdominal surgery
Author(s) -
SADEK S. A.,
CRANFORD C.,
ERIKSEN C.,
WALKER M.,
CAMPBELL C.,
BAKER P. R.,
WOOD R. A. B.,
CUSCHIERI A.
Publication year - 1988
Publication title -
alimentary pharmacology and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.308
H-Index - 177
eISSN - 1365-2036
pISSN - 0269-2813
DOI - 10.1111/j.1365-2036.1988.tb00671.x
Subject(s) - ceruletide , medicine , placebo , vomiting , nausea , anesthesia , rectum , gastroenterology , abdominal surgery , ileus , surgery , defecation , cholecystokinin , alternative medicine , receptor , pathology
SUMMARY In a double‐blind placebo‐controlled trial of patients undergoing elective abdominal surgery ( n =91), a single intravenous infusion of ceruletide (2.5 ng kg − ’min −1 ’for 1 hour) resulted in audible bowel sounds in 42/47 patients as opposed to 30/44 receiving placebo ( P < 0.025). Excessive bowel sounds were noted in 16 patients in the ceruletide group and four receiving placebo ( P < 0.01). Significantly more patients ( P < 0.01) in the ceruletide group (22/45 versus 9/44) passed flatus per rectum between the second and third post‐operative day. Ceruletide infusion was accompanied by a significant increase in the incidence of nausea and vomiting ( P < 0.005, P < 0.0025) but these side effects were short‐lived. These results indicate that ceruletide is likely to be a useful therapeutic agent for acute intestinal adynamic motility disorders.